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What Are The Main Causes of Aging

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1. Free radical levels in our body has to be maintained in a small quantity to make them helpful to our body. Excessive free radicals produced by oxidation, will accelerate your aging. Because free radicals can acquire electron from other molecules in our body thereby left that molecule and/or cell damaged. Excess free radicals are more easily generated in our body through oxidation by environmental pollutions and radiations (sun UV light). Antioxidants is a group of molecules that can neutralize free radicals thereby is a common component in anti-aging skin care formulas and anti-aging super foods/supplements.

2. Glycation here is a term referring to a type of chemical reaction between amino acids of the protein and aldehydes (such as glucose, sugar, called glycating agents). The glycating agents can cross link 2 proteins to form AGE (advanced glycation end products) by forming covalent bonds between protein and itself. AGE is very detrimental to our body in that they can bind to cells causing them to produce toxic chemical by-products. In addition, AGE stimulate the production of free radicals which in turn produce more aldehydes thereby forming a vicious cycle that will accelerate your aging. The natural substance discovered so far that is able to neutralize glycating agents is an expensive dipeptide nutrient called carnosine. The effect of glycation is reflected as unsightly wrinkled skin. In addition, glycation is also an underlying cause of age-related catastrophes including the neurologic, vascular, and eye disorders. Glycation is commonly measured in the body by estimating or monitoring the blood levels of glycosylated hemoglobin (Hba1c).

3. Methylation refers to the chemical reaction whereby molecules containing methyl group can be linked to various constituents of protein, DNA and other molecules. Methylation in our body must be balanced in order to keep proteins, DNA and other molecules function well. Homocysteine is a byproduct of an important methylation process in our body after methionion (an amino acid) is used to methylate protein and DNA. When homocysteine is in excess in our body, it is found to accelerate telemore (a structure involved in cell division) destruction and thereby causing or accelerating the aging process. On the other hand, methylation of certain part of DNA can turn off unnecessary or harmful genes and can block division of abnormal cells thereby prevent aging caused by these abnormal cells. How does our body balance methylation? There are three groups of molecules in our body regulate to balance methylation. They are vitamin B6, B12, Tri-Methyl-Glycine (TMG), and S-Adenosyl-Methionine (SAMe). As aging progresses, Vitamin B functioning as a cofactor in methylation reaction tend to become less efficient. SAMe formed in the body by combining methionion and ATP (adenosine triphosphate) is one of the most effective methylating agent.

4. It is believed that Chronic Inflammation is the cause of many age related damage, because excessive inflammation also produces excessive toxic chemicals which not only fight bacteria, but also destroy normal body cells. One example phenomenon of excessive inflammation is excitotoxicity where brain cells get over-excited. Another chemical factor in inflammation is tumor necrosis factor(TNF), excess TNF accelerates the degeneration of brain and nerves. Omega-s fish oil has been used for anti-inflammatory purposes, however it only handle one of the many inflammation components. The best known natural calorie restriction mimics resveratrol (an anti-inflammatory and an antioxidant) has been used to keep TNF as low as possible

5. DNA degeneration is an aging process in which DNA lose its ability to interact with RNA, the molecule directs the translation and synthesis of protein. The degeneration is then passed on to the new cells after DNA replication and cell division and therefore accelerate aging. Because of this, bio-active DNA repair molecules are an essential part of anti-aging superfoods.

6. It has been proposed that aging was partially a result of decreased energy production in the cell's mitochondria. In the presence of reduced mitochondrial function, cells become defective and lack the energy needed to effectively repair mutated or damaged DNA. This theory about the correlation of cell energy depletion and aging have been proved by published scientific studies since its proposal.

In summary, the six causes of aging described above are not isolated. They are interrelated. Many free radicals can also increase glycation (AGE). To see more detailed picture of Aging Process, visit our anti-aging web site

Author: dragon web profit
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Hong Gan
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